GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. Studies demonstrate that GW501516 can regulate expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Additionally, GW501516 has been shown to block insulin resistance and fatty acid-induced nuclear factor-κB (NF-κB) activation.
|Application||A selective and potent PPARβ agonist|
|Composition||94% PEG 400, 5% Ethanol, 1% GW-501516 (>99% purity)|
|Molar Mass||453.50 g/mol|
|Synonyms||Cardarine, Endurobol, GSK-516|
|Storage||Minimize open air exposure, store in a cool dry place|
|Terms||The products we offer are intended for laboratory research use only.|
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